Abstract
Circulating levels of cortisol, 17 alpha hydroxy progesterone and delta 4 androstenedione were analysed by specific radioimmunoassays in 11 patients with Cushing's disease before and at 2, 4, 6, 12 and 24# h following an oral dose of 400 mg ketoconazole. A significant fall in cortisol (26 - 79.6%, 59.8 +/- 18.7 SEM), delta 4 androstenedione (21.5 - 63.3%, 47.8 +/- 4.87) with a concomitant rise in 17 alpha hydroxy progesterone (113 - 218%, 116 +/- 11.43) were noted, suggesting inhibition of 17, 20 desmolase and 11 beta-hydroxylase enzymes in cortisol biosynthetic pathway.
MeSH terms
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17-alpha-Hydroxyprogesterone
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Aldehyde-Lyases / antagonists & inhibitors
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Androstenedione / blood
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Cushing Syndrome / blood
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Cushing Syndrome / drug therapy*
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Cytochrome P-450 Enzyme Inhibitors
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Female
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Humans
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Hydrocortisone / blood
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Hydroxyprogesterones / blood
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Ketoconazole / pharmacology*
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Male
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Steroid 11-beta-Hydroxylase / antagonists & inhibitors
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Steroid 17-alpha-Hydroxylase
Substances
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Cytochrome P-450 Enzyme Inhibitors
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Hydroxyprogesterones
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Androstenedione
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17-alpha-Hydroxyprogesterone
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Steroid 17-alpha-Hydroxylase
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Steroid 11-beta-Hydroxylase
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Aldehyde-Lyases
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Ketoconazole
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Hydrocortisone