Abstract
Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2] · 3H2O and K3[VO(O2)(C2O4)2] · 1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Tumor Cells, Cultured
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Vanadates / chemical synthesis
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Vanadates / chemistry
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Vanadates / pharmacology*
Substances
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Antineoplastic Agents
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bis(oxalato)oxoperoxovanadate(V)
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Vanadates