Association of endothelin-converting enzyme-1b C-338A polymorphism with increased risk of ischemic stroke in Chinese Han population

J Mol Neurosci. 2013 Oct;51(2):485-92. doi: 10.1007/s12031-013-0100-y. Epub 2013 Sep 13.

Abstract

Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in ECE-1 gene promoter, which has been reported to correlate with the risk of carotid atherosclerosis. We conducted a hospital-based case-control study of 309 patients with ischemic stroke and 309 controls matched on age and gender. The frequencies of ECE-1b-338 CC, CA, and AA genotypes in cases (45.0, 40.4, and 14.6 %) were significantly different from those of controls (53.1, 39.1, and 7.8 %, χ(2) = 8.519, P = 0.014), respectively. Compared with C carriers, A alleles showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds ratio (OR) = 1.42, 95 % CI = 1.11-1.81). After adjustment for potential risk factors, the AA genotype still kept positive correlation with ischemic stroke (OR = 1.78; 95 % CI = 1.06-3.54). In stratified analyses, the significant association of the A allele with ischemic stroke was observed in female subjects (adjusted OR = 1.64, 95 % CI = 1.17-2.89) and the subjects with age ≥ 64 years old (adjusted OR = 2.09, 95 % CI = 1.38-3.23). The present study suggested that the C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Alleles
  • Aspartic Acid Endopeptidases / genetics*
  • Brain Ischemia / diagnosis
  • Brain Ischemia / genetics*
  • Case-Control Studies
  • China
  • Endothelin-Converting Enzymes
  • Female
  • Genetic Predisposition to Disease
  • Heterozygote
  • Humans
  • Male
  • Metalloendopeptidases / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Sex Factors
  • Stroke / diagnosis
  • Stroke / genetics*

Substances

  • Aspartic Acid Endopeptidases
  • Metalloendopeptidases
  • ECE1 protein, human
  • Endothelin-Converting Enzymes