Hair follicle signaling networks: a dermal papilla-centric approach

Raul Ramos; Christian F Guerrero-Juarez; Maksim V Plikus

doi:10.1038/jid.2013.262

Hair follicle signaling networks: a dermal papilla-centric approach

J Invest Dermatol. 2013 Oct;133(10):2306-2308. doi: 10.1038/jid.2013.262.

Authors

Raul Ramos¹, Christian F Guerrero-Juarez¹, Maksim V Plikus²

Affiliations

¹ Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
² Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA. Electronic address: [email protected].

Abstract

Functional testing of dermal papilla (DP) signaling inputs into hair follicle (HF) morphogenesis and regeneration is becoming possible with the advent of new Cre lines. Targeted deletion of the signature genes in early DP precursors has revealed significant signaling redundancy during HF morphogenesis. Furthermore, the DP lineage commitment program can be exploited for generating highly inductive DP cells to be used in HF bioengineering assays.

Publication types

Comment

MeSH terms

Animals
Bone Morphogenetic Proteins / metabolism*
Dermis / embryology*
Female
Hair / growth & development*
Hair Follicle / embryology*
Hair Follicle / metabolism*
Lipase / genetics*
Male
Morphogenesis / physiology*
Phosphoric Diester Hydrolases / genetics*
Pregnancy
SOXB1 Transcription Factors / metabolism*

Substances

Bone Morphogenetic Proteins
SOXB1 Transcription Factors
Lipase
lipase H, mouse
Phosphoric Diester Hydrolases
alkylglycerophosphoethanolamine phosphodiesterase

Grants and funding

R25 GM055246/GM/NIGMS NIH HHS/United States