Fluorinated graphene oxide; a new multimodal material for biological applications

Adv Mater. 2013 Oct 18;25(39):5632-7. doi: 10.1002/adma201301804. Epub 2013 Aug 27.

Abstract

Fluorinated graphene oxide (FGO) is reported for the first time as a magnetically responsive drug carrier that can serve both as a magnetic resonance imaging (MRI) and photoacoustic contrast agent, under preclinical settings, and as a type of photothermal therapy. Its hydrophilic nature facilitates biocompatibility. FGO as a broad wavelength absorber, with high charge transfer and strong non-linear scattering is optimal for NIR laser-induced hyperthermia.

Keywords: drug delivery; magnetic resonance imaging (MRI); multifunctional graphene; photoacoustics; photothermal therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Ablation Techniques
  • Graphite / chemistry*
  • Graphite / therapeutic use
  • Graphite / toxicity
  • Halogenation*
  • Humans
  • MCF-7 Cells
  • Magnetic Resonance Imaging
  • Oxides / chemistry*

Substances

  • Oxides
  • Graphite