Ultrabright organic dots with aggregation-induced emission characteristics for real-time two-photon intravital vasculature imaging

Dan Ding; Chi Ching Goh; Guangxue Feng; Zujin Zhao; Jie Liu; Rongrong Liu; Nikodem Tomczak; Junlong Geng; Ben Zhong Tang; Lai Guan Ng; Bin Liu

doi:10.1002/adma.201301938

Ultrabright organic dots with aggregation-induced emission characteristics for real-time two-photon intravital vasculature imaging

Adv Mater. 2013 Nov 13;25(42):6083-8. doi: 10.1002/adma.201301938. Epub 2013 Aug 19.

Authors

Dan Ding¹, Chi Ching Goh, Guangxue Feng, Zujin Zhao, Jie Liu, Rongrong Liu, Nikodem Tomczak, Junlong Geng, Ben Zhong Tang, Lai Guan Ng, Bin Liu

Affiliation

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore.

PMID: 24038281
DOI: 10.1002/adma.201301938

Abstract

Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner.

Keywords: aggregation-induced emission; blood vascular imaging; nanoparticles; quantum dots; two-photon fluorescence imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiography
Animals
Blood Vessels / pathology*
Brain / diagnostic imaging
Contrast Media / chemistry
Nanoparticles / chemistry
Photons
Skin / diagnostic imaging
Spectroscopy, Near-Infrared
Thiadiazoles / chemistry*
Time-Lapse Imaging

Substances

Contrast Media
Thiadiazoles