Abstract
Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Ataxia Telangiectasia Mutated Proteins / metabolism*
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Ataxia Telangiectasia Mutated Proteins / radiation effects
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Cell Cycle Proteins
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Chromatin / metabolism*
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DNA Damage / physiology*
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Humans
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Models, Biological
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Nuclear Proteins / metabolism*
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Phosphorylation
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Radiation, Ionizing
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Signal Transduction / physiology*
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Signal Transduction / radiation effects
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Transcription Factors / metabolism*
Substances
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BRD4 protein, human
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Cell Cycle Proteins
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Chromatin
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Nuclear Proteins
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Transcription Factors
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Ataxia Telangiectasia Mutated Proteins