Abstract
Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004-2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010-2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation.
Keywords:
DRC; Democratic Republic of Congo; circulating VDPV; poliovirus; vaccine-derived poliovirus; viruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Capsid Proteins / genetics
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Communicable Diseases, Emerging / epidemiology
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Communicable Diseases, Emerging / prevention & control
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Communicable Diseases, Emerging / virology
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Democratic Republic of the Congo
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Feces / virology
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Humans
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Incidence
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Molecular Sequence Data
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Muscle Hypotonia / immunology
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Muscle Hypotonia / prevention & control
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Muscle Hypotonia / virology
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Paralysis / epidemiology
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Paralysis / prevention & control
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Paralysis / virology*
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Phylogeny
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Poliomyelitis / epidemiology
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Poliomyelitis / prevention & control
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Poliomyelitis / virology*
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Poliovirus / genetics*
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Poliovirus / immunology
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Poliovirus / isolation & purification
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Poliovirus Vaccine, Oral / genetics*
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Poliovirus Vaccine, Oral / immunology
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Sequence Analysis, DNA
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Vaccination*
Substances
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Capsid Proteins
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Poliovirus Vaccine, Oral
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VP1 protein, Poliovirus
Associated data
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GENBANK/JQ691358
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GENBANK/JQ691359
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GENBANK/JQ691360
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GENBANK/JQ691361
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GENBANK/JQ691362
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GENBANK/JQ691363
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GENBANK/JQ691364
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GENBANK/JQ691365
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GENBANK/JQ691366
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GENBANK/JQ691367
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GENBANK/JQ691368
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GENBANK/JQ691369
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GENBANK/JQ691370
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GENBANK/JQ691371
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GENBANK/JQ691375
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GENBANK/JQ691378
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GENBANK/JQ691379
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GENBANK/JQ691381
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GENBANK/JQ691382
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GENBANK/JQ691384
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