Calciphylaxis treated with sodium thiosulfate: report of two cases

Dermatol Online J. 2013 Sep 14;19(9):19616.

Abstract

Although traditionally observed in patients with end-stage renal disease and secondary hyperparathyroidism, calciphylaxis has been reported in patients with normal renal and parathyroid function. There is no evidence-based therapy available. The use of sodium thiosulfate (STS) has been increasingly described. Herein we describe two patients who responded well to this treatment.

Publication types

  • Case Reports

MeSH terms

  • Acenocoumarol / adverse effects
  • Acenocoumarol / therapeutic use
  • Aged
  • Aged, 80 and over
  • Atrial Fibrillation / drug therapy
  • Atrial Fibrillation / epidemiology
  • Calciphylaxis / diagnosis
  • Calciphylaxis / drug therapy*
  • Calciphylaxis / epidemiology
  • Calciphylaxis / etiology
  • Comorbidity
  • Diabetes Mellitus, Type 2 / epidemiology
  • Drug Substitution
  • Female
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Humans
  • Hyperparathyroidism, Secondary / complications
  • Livedo Reticularis / epidemiology
  • Obesity / epidemiology
  • Peripheral Vascular Diseases / epidemiology
  • Risk Factors
  • Shock, Septic / etiology
  • Thiosulfates / pharmacology
  • Thiosulfates / therapeutic use*
  • Urinary Tract Infections / complications
  • Vitamin D Deficiency / complications

Substances

  • Heparin, Low-Molecular-Weight
  • Thiosulfates
  • sodium thiosulfate
  • Acenocoumarol