Postanoxic myoclonus: two case presentations and review of medical management

Arch Phys Med Rehabil. 2014 Mar;95(3):588-90. doi: 10.1016/j.apmr.2013.09.008. Epub 2013 Sep 21.

Abstract

Postanoxic myoclonus is a rare manifestation after an anoxic event, with fewer than 150 cases reported in the literature. The condition is characterized by myoclonic jerks, which are worse on action than at rest, and postural lapses, ataxia, and dysarthria. The disability caused by postanoxic myoclonus can be profound, and treatment in the rehabilitation setting is exceptionally challenging. We present 2 patients who suffered from postanoxic myoclonus after an anoxic event, both of whom were successfully treated with a combination of levetiracetam, valproic acid, and clonazepam. These cases act as a framework for discussing the management of postanoxic myoclonus in the clinical setting.

Keywords: Case report; Myoclonus; Rehabilitation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / therapeutic use*
  • Clonazepam / administration & dosage
  • Clonazepam / therapeutic use*
  • Drug Therapy, Combination
  • Humans
  • Hypoxia / complications
  • Levetiracetam
  • Male
  • Middle Aged
  • Myoclonus / drug therapy*
  • Myoclonus / etiology
  • Piracetam / administration & dosage
  • Piracetam / analogs & derivatives*
  • Piracetam / therapeutic use
  • Valproic Acid / administration & dosage
  • Valproic Acid / therapeutic use*

Substances

  • Anticonvulsants
  • Levetiracetam
  • Clonazepam
  • Valproic Acid
  • Piracetam