Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYC(low)BCL2 (low) subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas

Acta Neuropathol. 2013 Oct;126(4):603-5. doi: 10.1007/s00401-013-1169-7. Epub 2013 Sep 6.

Authors

Anna Brunn¹, Inga Nagel, Manuel Montesinos-Rongen, Wolfram Klapper, Inga Vater, Werner Paulus, Volkmar Hans, Ingmar Blümcke, Joachim Weis, Reiner Siebert, Martina Deckert

Affiliation

¹ Department of Neuropathology, University Hospital of Cologne, Kerpener Str. 62, 50924, Cologne, Germany.

PMID: 24061549
DOI: 10.1007/s00401-013-1169-7

No abstract available

Publication types

Comparative Study
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor
Central Nervous System Neoplasms / genetics*
Central Nervous System Neoplasms / pathology*
Gene Expression Regulation, Neoplastic / genetics
Genes, bcl-2 / genetics*
Genes, myc / genetics*
Humans
Immunohistochemistry
Infant, Newborn
Lymphoma / genetics*
Lymphoma / pathology*
Lymphoma, Large B-Cell, Diffuse / genetics*
Lymphoma, Large B-Cell, Diffuse / pathology*
Prognosis
Proto-Oncogene Proteins c-bcl-6 / genetics*

Substances

Biomarkers, Tumor
Proto-Oncogene Proteins c-bcl-6