Abstract
Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Cell Line
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Drug Evaluation, Preclinical
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Drugs, Chinese Herbal / chemistry*
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Molecular Structure
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Oxidative Stress / drug effects
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Panax notoginseng / chemistry*
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Plant Roots / chemistry*
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Rats
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Sapogenins / chemistry
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Saponins / chemistry*
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Saponins / isolation & purification
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Saponins / pharmacology
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antioxidants
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Drugs, Chinese Herbal
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Sapogenins
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Saponins
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protopanaxatriol