Abstract
The bark of Litsea costalis affords two new compounds named 4,4'-diallyl-5,5'-dimethoxy-[1,1'-biphennyl]-2,2'-diol, biseugenol A (1) and 2,2'-oxybis (4-allyl-1-methoxybenzene), biseugenol B (2) along with two known compounds (3-4), namely 5-methoxy-2-Hydroxy Benzaldehyde (3), and (E)-4-styrylphenol (4). The structures of 1 and 2 were determined using 1D and 2D NMR data. Also, the IR and NMR data were combined with quantum chemical calculations in the DFT approach using the hybrid B3LYP exchange-correlation function to confirm the structures of the compounds. Compounds showed fairly potent anticancer activity against cell lines and antioxidant (DPPH).
Keywords:
Cytotoxicity; DFT calculations; Extraction; Litsea costalis; NMR.
Published by Elsevier B.V.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Biphenyl Compounds / chemistry*
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Biphenyl Compounds / isolation & purification
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Biphenyl Compounds / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Eugenol / analogs & derivatives*
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Eugenol / chemistry
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Eugenol / isolation & purification
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Eugenol / pharmacology
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Humans
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Litsea / chemistry*
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Litsea / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Phenyl Ethers / chemistry*
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Phenyl Ethers / isolation & purification
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Phenyl Ethers / pharmacology*
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Plant Bark / chemistry*
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Plant Bark / metabolism
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Quantum Theory
Substances
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2,2'-oxybis(4-allyl-1-methoxybenzene)
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4,4'-diallyl-5,5'-dimethoxy-(1,1'-biphenyl)-2,2'-diol
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Biphenyl Compounds
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Phenyl Ethers
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Eugenol