Genetic analysis of the fused in sarcoma gene in Chinese Han patients with Parkinson's disease

Kai Gao; Wen Zheng; Xiong Deng; Wei Xiong; Zhi Song; Yan Yang; Hao Deng

doi:10.1016/j.parkreldis.2013.09.010

Genetic analysis of the fused in sarcoma gene in Chinese Han patients with Parkinson's disease

Parkinsonism Relat Disord. 2014 Jan;20(1):119-21. doi: 10.1016/j.parkreldis.2013.09.010. Epub 2013 Sep 19.

Authors

Kai Gao¹, Wen Zheng², Xiong Deng¹, Wei Xiong³, Zhi Song⁴, Yan Yang⁴, Hao Deng⁵

Affiliations

¹ Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
² Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
³ Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, China.
⁴ Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
⁵ Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China. Electronic address: [email protected].

PMID: 24080306
DOI: 10.1016/j.parkreldis.2013.09.010

Abstract

Background and purpose: Exome sequencing in a large essential tremor (ET) family identified a novel nonsense mutation (p.Q290X) in the fused in sarcoma gene (FUS) as the cause of this family. Because of the clinical overlap between ET and Parkinson's disease (PD), the role of FUS in an independent cohort of PD patients from China mainland was evaluated.

Methods: The entire coding region of FUS in 508 Chinese Han patients with PD and the identified variants in 633 normal controls were evaluated. A variant was further screened in an additional 382 controls for the frequency in our population.

Results: A novel variant c.696C > T (p.Y232Y) in 2 sporadic patients with PD and six variants (c.52C > A, p.P18T; c.52C > T, p.P18S; c.147C > A, p.G49G; c.291C > T, p.Y97Y; c.684C > T, p.G228G; c.1176G > A, p.M392I) without significant difference in genotypic and allelic distributions in our PD cohort were identified.

Conclusion: The FUS gene is not a genetic risk factor for PD in the population of Chinese Han ethnicity.

Keywords: Essential tremor; FUS; Genetic; Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Asian People / genetics*
Female
Genetic Predisposition to Disease / genetics*
Humans
Male
Middle Aged
Parkinson Disease / genetics*
Polymerase Chain Reaction
RNA-Binding Protein FUS / genetics*

Substances

RNA-Binding Protein FUS