Abstract
The synthesis of benzimidazoles by intermolecular cyclization reaction of 2-iodoanilines with nitriles has been developed. These reactions proceeded without the aid of any transition metals or ligands and just using KOBu(t) as the base. A variety of substituted benzimidazole derivatives can be synthesized by the approach.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aniline Compounds / chemistry*
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / chemistry*
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Butanols / chemistry*
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Catalysis
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Chemistry Techniques, Synthetic
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Cyclization
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Nitriles / chemistry*
Substances
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2-iodobenzenamine
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Aniline Compounds
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Benzimidazoles
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Butanols
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Nitriles
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tert-butoxide, potassium
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benzimidazole