A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.
Keywords: cancer stem cells; glioblastoma multiforme; immunosuppression; microRNAs; regulatory T cells; signal transducer and activator of transcription 3.