Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors

Leuk Lymphoma. 2014 Jul;55(7):1670-4. doi: 10.3109/10428194.2013.845886. Epub 2013 Nov 14.

Authors

Chadi Al-Nawakil¹, Lise Willems, Cedric Mauprivez, Benjamin Laffy, Mona Benm'rad, Jerome Tamburini, Helene Fontaine, Philippe Sogni, Benoit Terris, Didier Bouscary, Laurence Moachon

Affiliation

¹ Unité Fonctionnelle d'Hématologie.

PMID: 24090500
DOI: 10.3109/10428194.2013.845886

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Agents / administration & dosage
Antineoplastic Agents / adverse effects*
Antineoplastic Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Asparaginase / administration & dosage
Asparaginase / adverse effects*
Asparaginase / therapeutic use
Chemical and Drug Induced Liver Injury / diagnosis
Chemical and Drug Induced Liver Injury / drug therapy*
Coenzymes / administration & dosage
Coenzymes / therapeutic use*
Fatal Outcome
Female
Humans
Liver / metabolism
Liver / pathology
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Treatment Outcome

Substances

Antineoplastic Agents
Coenzymes
Asparaginase