Abstract
Bacterial lipopeptides, known for their antibiotic activities, have been tested for their ability to interact with lipid membranes. These lipopeptides, Iturin A, Bacillomycin L and D and Peptidolipin NA present analogous structural characteristics: a heptapeptidic cycle is linked to a hydrocarbon chain. We present evidence that these lipopeptides modify the conductance of planar bilayers by forming ion-conducting pores.
MeSH terms
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Anti-Bacterial Agents*
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Antimicrobial Cationic Peptides
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Ion Channels / metabolism
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Lipid Bilayers / metabolism*
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Lipopeptides
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Lipoproteins / metabolism*
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Membrane Potentials
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Peptides*
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Peptides, Cyclic / metabolism
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Time Factors
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Ion Channels
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Lipid Bilayers
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Lipopeptides
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Lipoproteins
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Peptides
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Peptides, Cyclic
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peptidolipin NA
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iturin A
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bacillomycin L
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bacillomycin D