Abstract
We describe a case of antiviral-resistant cytomegalovirus meningoencephalitis occurring after hematopoietic stem cell transplantation. Antiviral-resistant cytomegalovirus was identified in blood 16 months earlier. However, wild-type cytomegalovirus was evidenced in blood when the meningoencephalitis was diagnosed. Treatment of meningoencephalitis should be adapted to all previously identified resistance mutations in any compartment.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Antiviral Agents / pharmacology*
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Blood / virology
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Cytomegalovirus / drug effects
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Cytomegalovirus / isolation & purification*
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Cytomegalovirus Infections / diagnosis*
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Cytomegalovirus Infections / virology*
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DNA, Viral / genetics
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Drug Resistance, Viral*
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Hematopoietic Stem Cell Transplantation / adverse effects
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Humans
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Infant
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Male
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Meningoencephalitis / diagnosis*
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Meningoencephalitis / virology*
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Polymerase Chain Reaction
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Time Factors
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Viral Proteins / genetics
Substances
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Antiviral Agents
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DNA, Viral
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Viral Proteins