Dictionary learning improves subtyping of breast cancer aCGH data

Annu Int Conf IEEE Eng Med Biol Soc. 2013:2013:604-7. doi: 10.1109/EMBC.2013.6609572.

Abstract

The advent of Comparative Genomic Hybridization (CGH) data led to the development of new mathematical models and computational methods to automatically infer chromosomal alterations. In this work we tackle a standard clustering problem exploiting the good representation properties of a novel method based on dictionary learning. The identified dictionary atoms, which show co-occuring shared alterations among samples, can be easily interpreted by domain experts. We compare a state-of-the-art approach with an original method on a breast cancer dataset.

MeSH terms

  • Algorithms
  • Breast Neoplasms / genetics*
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 8 / genetics
  • Cluster Analysis
  • Comparative Genomic Hybridization / methods*
  • Female
  • Genome-Wide Association Study
  • Humans
  • Models, Theoretical