Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12020-3. doi: 10.1002/anie.201304660. Epub 2013 Sep 24.

Authors

Andreas Brust¹, Ching-I A Wang, Norelle L Daly, Joseph Kennerley, Mahsa Sadeghi, Macdonald J Christie, Richard J Lewis, Mehdi Mobli, Paul F Alewood

Affiliation

¹ Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia). [email protected].

PMID: 24115503
DOI: 10.1002/anie.201304660

No abstract available

Keywords: biological activity; combinatorial chemistry; cyclic peptides; drug discovery; peptidomimetics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenergic Uptake Inhibitors / blood
Adrenergic Uptake Inhibitors / chemical synthesis
Adrenergic Uptake Inhibitors / chemistry
Amino Acid Sequence
Animals
Disulfides / chemistry*
Drug Evaluation, Preclinical
Half-Life
Humans
Magnetic Resonance Spectroscopy
Norepinephrine Plasma Membrane Transport Proteins / antagonists & inhibitors*
Norepinephrine Plasma Membrane Transport Proteins / metabolism
Peptides, Cyclic / blood
Peptides, Cyclic / chemical synthesis
Peptides, Cyclic / chemistry
Peptidomimetics*
Protein Structure, Tertiary
Rats

Substances

Adrenergic Uptake Inhibitors
Disulfides
Norepinephrine Plasma Membrane Transport Proteins
Peptides, Cyclic
Peptidomimetics