Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide

Zhen-Wei Wu; Hai-Wei Xu; Gui-Fu Dai; Meng-Jiao Liu; Li-Ping Zhu; Jian Wu; Ya-Nan Wang; Feng-Juan Wu; Dan Zhao; Ming-Fu Gao; Shan-Shan Nie; Wei Han; Jing-Hui Song; Hong-Min Liu

doi:10.1016/j.bmcl.2013.09.049

Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6421-6. doi: 10.1016/j.bmcl.2013.09.049. Epub 2013 Sep 25.

Authors

Zhen-Wei Wu¹, Hai-Wei Xu, Gui-Fu Dai, Meng-Jiao Liu, Li-Ping Zhu, Jian Wu, Ya-Nan Wang, Feng-Juan Wu, Dan Zhao, Ming-Fu Gao, Shan-Shan Nie, Wei Han, Jing-Hui Song, Hong-Min Liu

Affiliation

¹ Department of Biotechnology, Zhengzhou University, Zhengzhou 450001, PR China.

PMID: 24120543
DOI: 10.1016/j.bmcl.2013.09.049

Abstract

In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure-activity relationships were studied. Compared to 1, compounds 8a-8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.

Keywords: Andrographolide; Derivative; Invasion; MMP-9; Migration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Movement / drug effects*
Cell Proliferation / drug effects
Diterpenes / chemical synthesis
Diterpenes / chemistry*
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Neoplasms / drug therapy*
Neoplasms / pathology
Structure-Activity Relationship

Substances

Diterpenes
andrographolide