Abstract
Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller than that of immunoglobulin heavy-chain or light-chain genes. We suggest that beta-chain somatic diversification is concentrated at the V beta-D beta-J beta junctions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Epitopes
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Gene Expression Regulation
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Genes
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Macromolecular Substances
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Major Histocompatibility Complex
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Mice
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Mutation
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Receptors, Antigen, T-Cell / genetics*
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Recombination, Genetic
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T-Lymphocytes / physiology*
Substances
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Epitopes
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Macromolecular Substances
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Receptors, Antigen, T-Cell
Associated data
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GENBANK/X02778
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GENBANK/X02779
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GENBANK/X02780
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GENBANK/X02781
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GENBANK/X02782
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GENBANK/X02783
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GENBANK/X02784
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GENBANK/X02785