Abstract
A new series of 64-valent glycodendrimers was prepared in excellent yield and purity using a divergent and iterative strategy based on oxime ligation. Enzyme-linked lectin assays revealed the first nanomolar inhibitor for the fucose-specific lectin isolated from Ulex europaeus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Dendrimers / chemical synthesis*
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Dendrimers / chemistry
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Glycoconjugates / chemical synthesis*
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Glycoconjugates / chemistry
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Molecular Structure
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Oximes / chemistry*
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Peptides, Cyclic / chemistry*
Substances
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Dendrimers
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Glycoconjugates
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Oximes
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Peptides, Cyclic