The article reports on childhood predictors (explanatory, behavioral and offenses) to predict homicide offenders in the longitudinal Pittsburgh Youth Study, and compares these predictors with predictors of homicide victims in the same study. This forms the basis for formulating antecedents that are shared between homicide offenders and homicide victims at a young age (ages 7–11) and antecedents that are not shared or are unique for each. Implications of the research are highlighted for early intervention and for interventions with high-risk offenders.