Development of a novel multifunctional n,p ligand for highly enantioselective palladium-catalyzed asymmetric allylic etherification of alcohols and silanols

Chemistry. 2013 Nov 11;19(46):15452-7. doi: 10.1002/chem.201303233. Epub 2013 Oct 10.

Abstract

CycloN2P2-Phos! The use of the multidentate phosphine, CycloN2P2-Phos, which contains four heteroatoms (two nitrogen and two phosphorus atoms), in the palladium-catalyzed asymmetric allylic etherification (AAE) of alcohols and silanols leads to excellent levels of enantioselectivity (up to 99 % ee).

Keywords: allylic etherification; asymmetric catalysis; chiral ligands; palladium; silanols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Allyl Compounds / chemistry*
  • Catalysis
  • Ethers / chemistry*
  • Ligands
  • Molecular Structure
  • Palladium / chemistry*
  • Phosphines / chemistry*
  • Silanes / chemistry*
  • Stereoisomerism

Substances

  • Alcohols
  • Allyl Compounds
  • Ethers
  • Ligands
  • Phosphines
  • Silanes
  • silanol
  • Palladium