Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature

Background: Primary cutaneous amyloidosis of the penis is a rare entity.

Objectives: We describe two cases of primary penile cutaneous amyloidosis presenting as localized lesions on the penis and not associated with systemic amyloidosis.

Methods: A comprehensive literature review of all published cases.

Results: The rarest form of cutaneous amyloidosis, nodular amyloidosis, is the most frequent presentation of penis-limited cutaneous amyloid with a low incidence of systemic disease progression.

Conclusions: Although primary nodular amyloidosis is a rare entity it seems to be the most frequent presentation of penile-limited cutaneous disease, with a low incidence of systemic involvement.