Abstract
Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.
MeSH terms
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Cell Line, Tumor
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Cell Nucleus / chemistry
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Cell Nucleus / metabolism
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Cell Survival / drug effects
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Drug Carriers / chemistry*
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Folic Acid / chemistry*
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HeLa Cells
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Humans
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Hydroxides / chemistry*
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Methotrexate / chemistry
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Methotrexate / toxicity
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Microscopy, Confocal
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Nanoparticles / chemistry*
Substances
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Drug Carriers
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Hydroxides
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hydroxide ion
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Folic Acid
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Methotrexate