Sustained virological response to antiviral treatment in chronic hepatitis C patients may be predictable by HCV-RNA clearance in peripheral blood mononuclear cells

Nicola Coppola; Stefania De Pascalis; Mariantonietta Pisaturo; Laurenza Paradiso; Margherita Macera; Nicolina Capoluongo; Loredana Alessio; Maria Stanzione; Caterina Sagnelli; Carmine Minichini; Evangelista Sagnelli

doi:10.1016/j.jcv.2013.09.014

Sustained virological response to antiviral treatment in chronic hepatitis C patients may be predictable by HCV-RNA clearance in peripheral blood mononuclear cells

J Clin Virol. 2013 Dec;58(4):748-50. doi: 10.1016/j.jcv.2013.09.014. Epub 2013 Sep 23.

Authors

Nicola Coppola¹, Stefania De Pascalis, Mariantonietta Pisaturo, Laurenza Paradiso, Margherita Macera, Nicolina Capoluongo, Loredana Alessio, Maria Stanzione, Caterina Sagnelli, Carmine Minichini, Evangelista Sagnelli

Affiliation

¹ Department of Mental and Public Health, Section of Infectious Diseases, Second University of Naples, Italy.

PMID: 24140030
DOI: 10.1016/j.jcv.2013.09.014

No abstract available

Keywords: CHC; HCV; PBMC; Peg-IFN; RVR; SVR; chronic hepatitis C; hepatitis C virus; pegylated-interferon; peripheral blood mononuclear cells; rapid virological response; sustained virological response.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antiviral Agents / therapeutic use*
Female
Hepacivirus / genetics
Hepacivirus / physiology*
Hepatitis C, Chronic / blood
Hepatitis C, Chronic / drug therapy*
Hepatitis C, Chronic / virology*
Humans
Interferon-alpha / therapeutic use
Leukocytes, Mononuclear / virology*
Male
Middle Aged
Polyethylene Glycols / therapeutic use
Predictive Value of Tests
RNA, Viral / blood*
Recombinant Proteins / therapeutic use
Ribavirin / therapeutic use
Treatment Outcome
Virus Replication / drug effects*

Substances

Antiviral Agents
Interferon-alpha
RNA, Viral
Recombinant Proteins
Polyethylene Glycols
Ribavirin
peginterferon alfa-2a