Abstract
We studied antioxidant activity of new derivative of pyrrolo[1,2-α]benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical properties. RU-792 was superior to Trolox by antioxidant activity in the models of Fe(2+)-induced chemiluminescence of lipids with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), but less effective in the model of luminol-dependent chemiluminescence.
MeSH terms
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Benzimidazoles / chemistry*
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Benzothiazoles / chemistry
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Biphenyl Compounds / chemistry
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Chromans / chemistry
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Free Radical Scavengers / chemistry*
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Free Radicals / chemistry
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Kinetics
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Lipid Peroxidation
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Oxidation-Reduction
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Picrates / chemistry
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Pyrroles / chemistry*
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Sulfonic Acids / chemistry
Substances
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Benzimidazoles
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Benzothiazoles
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Biphenyl Compounds
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Chromans
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Free Radical Scavengers
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Free Radicals
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Picrates
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Pyrroles
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RU-792
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Sulfonic Acids
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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1,1-diphenyl-2-picrylhydrazyl
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6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid