Abstract
Eight patients with disseminated Hodgkin's disease resistant to MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) chemotherapy were treated with high-dose chemoradiotherapy and marrow transplantation from an HLA-identical sibling. Two patients remain alive in unmaintained complete remission (CR) at 38 and 39 months after transplant. In the other six patients, reasons for failure included relapse of lymphoma (two patients), or death due to complications of the transplant procedure, including Legionnaire's disease, disseminated zoster, graft-v-host disease, and aspiration pneumonia secondary to severe mucositis. These results demonstrate that some patients with MOPP-resistant Hodgkin's disease can obtain prolonged CR following intensive chemoradiotherapy and allogeneic marrow transplantation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Bone Marrow Transplantation*
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Combined Modality Therapy
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Dacarbazine / administration & dosage
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Doxorubicin / administration & dosage
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Drug Resistance
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Female
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Graft vs Host Disease / etiology
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Herpes Zoster / etiology
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Hodgkin Disease / mortality
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Hodgkin Disease / radiotherapy
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Hodgkin Disease / therapy*
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Humans
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Legionnaires' Disease / etiology
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Male
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Mechlorethamine / administration & dosage
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Pneumonia, Aspiration / etiology
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Postoperative Complications / mortality
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Prednisone / administration & dosage
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Procarbazine / administration & dosage
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Time Factors
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Transplantation, Homologous
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Vinblastine
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Vincristine / administration & dosage
Substances
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Bleomycin
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Procarbazine
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Mechlorethamine
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Vincristine
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Vinblastine
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Dacarbazine
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Doxorubicin
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Prednisone
Supplementary concepts
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ABVD protocol
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MOPP protocol