[Role of Follicular helper CD4 T cells in HIV/SIV infection]

Uirusu. 2012;62(2):161-6. doi: 10.2222/jsv.62.161.
[Article in Japanese]

Abstract

Follicular CD4 T helper (TFH) cells promote the survival, isotype switching and generation of high affinity memory B cells and plasma cells. There are numerous reports regarding the dysfunction of B cell mediated immune responses, the lack of memory CD4 T cells and the dysfunction of HIV specific CD4 T cells in SIV/HIV infection. During chronic SIV/HIV infection, TFH cell accumulation may drive B cell dysfunction and become a major HIV reservoir. In this review, we discuss the relationship between TFH cells and B cells in SIV/HIV infection.

Publication types

  • English Abstract
  • Review

MeSH terms

  • AIDS Vaccines
  • Animals
  • B-Lymphocytes / immunology*
  • Germinal Center
  • HIV / physiology*
  • HIV Infections / immunology*
  • HIV Infections / virology*
  • Haplorhini
  • Humans
  • Immunologic Memory
  • Lymphatic System / immunology
  • Lymphatic System / virology
  • Mutation
  • SAIDS Vaccines
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Acquired Immunodeficiency Syndrome / virology*
  • Simian Immunodeficiency Virus / physiology*
  • Somatic Hypermutation, Immunoglobulin
  • T-Lymphocytes, Helper-Inducer / immunology*
  • Virus Replication*

Substances

  • AIDS Vaccines
  • SAIDS Vaccines