Failure of fourth-generation enzyme immunoassay in HIV screening and plasma HIV-1 RNA detection in recent high-risk behavior

Sarah Maylin; Sébastien Fouéré; François Simon; Constance Delaugerre

doi:10.1159/000355315

Failure of fourth-generation enzyme immunoassay in HIV screening and plasma HIV-1 RNA detection in recent high-risk behavior

Intervirology. 2014;57(1):49-51. doi: 10.1159/000355315. Epub 2013 Oct 18.

Authors

Sarah Maylin¹, Sébastien Fouéré, François Simon, Constance Delaugerre

Affiliation

¹ Laboratoire de Microbiologie, AP-HP-Hôpital Saint Louis, Paris, France.

PMID: 24157685
DOI: 10.1159/000355315

Abstract

Acute HIV infection was not detected in a young man presenting symptoms of sexual disease infection using fourth-generation screening tests combining HIV-specific antibody and p24 antigen. Detection of plasma HIV-1 RNA concomitant with screening tests may be proposed in individuals presenting with a symptomatic sexually transmitted infection.

Publication types

Case Reports

MeSH terms

Diagnostic Errors*
HIV Antibodies / blood
HIV Antigens / blood
HIV Infections / diagnosis*
HIV-1 / genetics
HIV-1 / immunology
HIV-1 / isolation & purification*
Humans
Immunoenzyme Techniques / methods
Male
Molecular Diagnostic Techniques / methods*
RNA, Viral / blood
Risk-Taking
Virology / methods*
Young Adult

Substances

HIV Antibodies
HIV Antigens
RNA, Viral