Molecular mimicry and original biochemical strategies for the biogenesis of a Legionella pneumophila replicative niche in phagocytic cells

Julie Allombert; Fabien Fuche; Céline Michard; Patricia Doublet

doi:10.1016/j.micinf.2013.09.007

Molecular mimicry and original biochemical strategies for the biogenesis of a Legionella pneumophila replicative niche in phagocytic cells

Microbes Infect. 2013 Dec;15(14-15):981-8. doi: 10.1016/j.micinf.2013.09.007. Epub 2013 Oct 24.

Authors

Julie Allombert¹, Fabien Fuche, Céline Michard, Patricia Doublet

Affiliation

¹ CIRI, Centre for Infectiology Research, Legionella Pathogenesis Team, Université de Lyon, Lyon, France; Inserm, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France; CNRS, UMR5308, Lyon, France.

PMID: 24161959
DOI: 10.1016/j.micinf.2013.09.007

Abstract

Legionella pneumophila is a paradigm of highly adapted intravacuolar pathogens that acquired the rare ability to replicate within a phagocytic cell. Here, we review recent progress about the role of Type 4 secretion system effectors involved in the biogenesis of the replicative niche, the Legionella containing vacuole.

Keywords: Host pathways subversion; Intravacuolar pathogen; Legionella containing vacuole; Type 4 secretion system effectors; Vesicular trafficking.

Publication types

Review

MeSH terms

Bacterial Secretion Systems / physiology
Humans
Intracellular Space / metabolism
Intracellular Space / microbiology
Legionella pneumophila / physiology*
Legionnaires' Disease / microbiology*
Molecular Mimicry*
Monomeric GTP-Binding Proteins / metabolism
Phagocytes / microbiology*
Vacuoles / metabolism

Substances

Bacterial Secretion Systems
Monomeric GTP-Binding Proteins