Abstract
Two new phenanthrene glycosides, dioscopposide A and dioscopposide B (1 and 2), were isolated from the rhizomes of Dioscorea opposita. Their structures were determined primarily on the basis of 1D and 2D NMR techniques, MS studies, and chemical methods. All the isolates were evaluated for their inhibitory effects on the lipopolysaccharide-induced nitric oxide production using murine macrophage RAW 264.7 cells. The IC50 values of dioscopposide A and dioscopposide B were 5.8 and 7.2 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dioscorea / chemistry*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Inhibitory Concentration 50
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification*
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Phenanthrenes / pharmacology
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Rhizome / chemistry
Substances
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Drugs, Chinese Herbal
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Glycosides
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Lipopolysaccharides
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Phenanthrenes
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dioscopposide A
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dioscopposide B
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Nitric Oxide