Pimarane diterpenes from the Arctic fungus Eutypella sp. D-1

J Antibiot (Tokyo). 2014 Feb;67(2):171-4. doi: 10.1038/ja.2013.104. Epub 2013 Oct 30.

Abstract

Two new diterpenes, libertellenone G(1) and libertellenone H(2) were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of Arctic, together with two known pimarane diterpenes (3-4). The structures of 1 and 2 were elucidated from spectroscopic data (nuclear magnetic resonance, mass spectrometry and infrared). These compounds were evaluated for cytotoxic activity against seven human tumor cell lines. Compound 2 showed a range of cytotoxicity between 3.31 and 44.1 μM. Compound 1 exhibited antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry
  • Abietanes / isolation & purification
  • Abietanes / pharmacology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Arctic Regions
  • Bacillus subtilis / drug effects
  • Cell Line, Tumor
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Drug Discovery
  • Escherichia coli / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Soil Microbiology
  • Staphylococcus aureus / drug effects
  • Xylariales / chemistry*

Substances

  • Abietanes
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Diterpenes
  • libertellenone G
  • libertellenone H