pH-Triggered Au-fluorescent mesoporous silica nanoparticles for 19F MR/fluorescent multimodal cancer cellular imaging

Chem Commun (Camb). 2014 Jan 11;50(3):283-5. doi: 10.1039/c3cc47324d. Epub 2013 Oct 30.

Abstract

Novel pH-triggered nanoprobe were fabricated for (19)F MRI and fluorescence imaging (MRI-FI) of cancer cells. The biocompatibility, durability, high internalizing efficiency and pore architecture justify the Au-fluorescent mesoporous silica nanoparticles as ideal, highly sensitive and highly specific vectors for (19)F MRI and FI of cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Contrast Media / chemistry
  • Contrast Media / metabolism
  • Fluorine / chemistry
  • Gold / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Imaging*
  • Microscopy, Fluorescence
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Neoplasms / diagnostic imaging
  • Neoplasms / metabolism
  • Porosity
  • Radiography
  • Silicon Dioxide / chemistry*

Substances

  • Contrast Media
  • Fluorine
  • Gold
  • Silicon Dioxide