Exploring adenylylation and phosphocholination as post-translational modifications

Chembiochem. 2014 Jan 3;15(1):19-26. doi: 10.1002/cbic.201300508. Epub 2013 Oct 31.

Abstract

Editing the translations: Adenylylation and phosphocholination have recently been found as important post-translational modifications used by pathogenic bacteria during the infection process. This review discusses the combined use of chemical handles and specific antibodies for the identification of previously unknown substrates of these post-translational modifications in infected host cells.

Keywords: adenylylation; antibodies; bioorganic chemistry; mass spectrometry; phosphocholination; post-translational modifications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / chemistry
  • Adenosine / metabolism*
  • Antibodies / immunology
  • Bacteria / metabolism
  • Enzymes / metabolism
  • Peptides / analysis
  • Peptides / chemical synthesis
  • Phosphorylcholine / chemistry
  • Phosphorylcholine / metabolism*
  • Protein Processing, Post-Translational*

Substances

  • Antibodies
  • Enzymes
  • Peptides
  • Phosphorylcholine
  • Adenosine