Abstract
Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.
MeSH terms
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CD28 Antigens / metabolism
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DNA Methylation
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / metabolism
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Gene Expression Regulation
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Humans
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Receptors, Antigen, T-Cell / metabolism
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Receptors, Interleukin-2 / metabolism
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Signal Transduction*
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism*
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Thymus Gland / immunology*
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Thymus Gland / metabolism*
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Transcription Factors / metabolism*
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Transcription, Genetic
Substances
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CD28 Antigens
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FOXP3 protein, human
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Forkhead Transcription Factors
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Receptors, Antigen, T-Cell
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Receptors, Interleukin-2
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Transcription Factors