Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report

Asia Pac J Clin Oncol. 2016 Mar;12(1):e196-8. doi: 10.1111/ajco.12129. Epub 2013 Nov 5.

Abstract

We report a case of transient sixth nerve palsy after systemic administration of bevacizumab. Two days after systemic administration of bevacizumab in conjunction with gemcitabine and carboplatin in a 67-year-old woman with recurrent primary ovarian cancer, the patient developed sixth nerve palsy. After bevacizumab was stopped, the complete left sixth nerve palsy resolved spontaneously over the course of 3 months. This is the first reported case of bevacizumab-induced cranial sixth nerve palsy in the treatment of gynecologic malignancy.

Publication types

  • Case Reports

MeSH terms

  • Abducens Nerve Diseases / chemically induced*
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Bevacizumab / administration & dosage
  • Bevacizumab / adverse effects*
  • Carboplatin / administration & dosage
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives
  • Female
  • Gemcitabine
  • Humans
  • Neoplasm Recurrence, Local / drug therapy
  • Ovarian Neoplasms / drug therapy*

Substances

  • Deoxycytidine
  • Bevacizumab
  • Carboplatin
  • Gemcitabine