Evidence of vaccine-related reassortment of rotavirus, Brazil, 2008-2010

Emerg Infect Dis. 2013 Nov;19(11):1843-6. doi: 10.3201/eid1911.121407.

Abstract

Analysis of 27 rotavirus strains from vaccinated and unvaccinated children revealed reassortment events in 3 strains: a gene derived from a vaccine; a gene acquired from a circulating strain; and reassortment between circulating strains. Data suggest that the widespread use of this monovalent rotavirus vaccine may introduce vaccine genes into circulating human rotaviruses or vice versa.

Keywords: Brazil; G1P[8] strains; RVA; Rotarix; phylogenetic analysis; reassortment; rotavirus; vaccine; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brazil / epidemiology
  • Genes, Viral
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Reassortant Viruses*
  • Rotavirus / classification
  • Rotavirus / genetics*
  • Rotavirus / immunology*
  • Rotavirus Infections / epidemiology*
  • Rotavirus Infections / prevention & control
  • Rotavirus Infections / virology*
  • Rotavirus Vaccines / adverse effects*
  • Rotavirus Vaccines / immunology

Substances

  • Rotavirus Vaccines

Associated data

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