Failure to detect anti-MAG antibodies by RIA in CSF of patients with multiple sclerosis

J Neuroimmunol. 1986 Apr;11(2):165-9. doi: 10.1016/0165-5728(86)90117-7.

Abstract

Using a sensitive double-antibody radioimmunoassay (RIA) we measured IgG antibodies to the myelin-associated glycoprotein (MAG) in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) and with other neurological diseases (OND). Comparable levels of precipitation of radiolabeled MAG were obtained with CSF from the patients of the two groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Humans
  • Immunoglobulin G / cerebrospinal fluid
  • Immunoglobulin G / immunology
  • Mice / immunology
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / immunology
  • Myelin Proteins / cerebrospinal fluid*
  • Myelin Proteins / immunology
  • Myelin-Associated Glycoprotein
  • Radioimmunoassay

Substances

  • Antibodies, Monoclonal
  • Immunoglobulin G
  • Myelin Proteins
  • Myelin-Associated Glycoprotein