Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy

Orhan Ates; Habip Bilen; Sadullah Keles; H Hakan Alp; Mevlüt Sait Keleş; Kenan Yıldırım; Osman Ondaş; L Can Pınar; Mustafa Civelekler; Orhan Baykal

doi:10.3980/j.issn.2222-3959.2013.05.24

Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy

Int J Ophthalmol. 2013 Oct 18;6(5):675-9. doi: 10.3980/j.issn.2222-3959.2013.05.24. eCollection 2013.

Authors

Orhan Ates¹, Habip Bilen, Sadullah Keles, H Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Ondaş, L Can Pınar, Mustafa Civelekler, Orhan Baykal

Affiliation

¹ Department of Ophthalmology, Medical School of Ataturk University, Erzurum 25240, Turkey.

PMID: 24195048
PMCID: PMC3808920
DOI: 10.3980/j.issn.2222-3959.2013.05.24

Abstract

Aim: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.

Methods: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50). The control group was consist of healthy individuals (n=50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups.

Results: Ubiquinone-10 (Coenzyme Q10) levels in PDRP and control subjects are 3.81±1.19µmol/L and 1.91±0.62µmol/L, respectively. Plasma MDA levels in PDRP and control subjects were 8.16±2µmol/L and 3.44±2.08µmol/L, respectively. Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68, respectively.

Conclusion: The ratio of ubiquinol-10/ubiquinone-10 is found lower in patients with PDRP. High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.

Keywords: coenzyme Q10; diabetic; retinopathy.