Consensus document of the Neuroendocrinology area of the Spanish Society of Endocrinology and Nutrition on management of hypopituitarism during transition

Endocrinol Nutr. 2014 Feb;61(2):68.e1-68.e11. doi: 10.1016/j.endonu.2013.08.001. Epub 2013 Nov 5.
[Article in English, Spanish]

Abstract

The transition period from child to adult represents a crucial phase in the growth process where multiple physical and psychosocial changes occur. It has been arbitrarily defined as the period extending from late puberty to full adult maturity (i.e., from mid to late teenage years until 6-7 years after achievement of final height). The aim of this guideline is to emphasize the importance of adequate hormone replacement during this period and to review reassessment of pituitary function. In patients with GH deficiency diagnosed in childhood, an attempt is made to answer when to retest GH secretion, when to treat and how they should be monitored. Thyroxine, glucocorticoid, and sex steroid replacement are also reviewed.

Keywords: Adrenal insufficiency; Deficiencia de hormona de crecimiento; Growth hormone deficiency; Growth hormone stimulation test; Hipogonadismo; Hipopituitarismo; Hipotiroidismo, Insuficiencia adrenal; Hormone replacement; Hypogonadism; Hypopituitarism; Hypothyroidism; Período de transición; Sustitución hormonal; Test de estímulo de la hormona de crecimiento; Transition period.

Publication types

  • Consensus Development Conference
  • Practice Guideline

MeSH terms

  • Adolescent
  • Adult
  • Body Composition / drug effects
  • Child
  • Child Development / drug effects
  • Drug Monitoring
  • Endocrine System Diseases / drug therapy
  • Endocrine System Diseases / etiology
  • Female
  • Growth / drug effects
  • Growth Hormone-Releasing Hormone
  • Hormone Replacement Therapy*
  • Human Growth Hormone / administration & dosage
  • Human Growth Hormone / deficiency
  • Human Growth Hormone / therapeutic use*
  • Humans
  • Hypopituitarism / drug therapy*
  • Hypothalamo-Hypophyseal System / physiopathology
  • Male
  • Pituitary-Adrenal System / physiopathology
  • Puberty
  • Transition to Adult Care*

Substances

  • Human Growth Hormone
  • Growth Hormone-Releasing Hormone