Gating pluripotency via nuclear pores

Jiping Yang; Ning Cai; Fei Yi; Guang-Hui Liu; Jing Qu; Juan Carlos Izpisua Belmonte

doi:10.1016/j.molmed.2013.10.003

Gating pluripotency via nuclear pores

Trends Mol Med. 2014 Jan;20(1):1-7. doi: 10.1016/j.molmed.2013.10.003. Epub 2013 Nov 7.

Authors

Jiping Yang¹, Ning Cai¹, Fei Yi², Guang-Hui Liu³, Jing Qu⁴, Juan Carlos Izpisua Belmonte⁵

Affiliations

¹ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
² Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
³ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Beijing Institute for Brain Disorders, Beijing, China. Electronic address: [email protected].
⁴ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: [email protected].
⁵ Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: [email protected].

PMID: 24211182
DOI: 10.1016/j.molmed.2013.10.003

Abstract

In recent years, growing evidence has pointed to the interesting idea that pluripotency might be regulated by a nuclear-pore-coordinated network that controls the level of pluripotency factors in the nucleus. A thorough understanding of this process might improve our comprehension of cell pluripotency and differentiation during embryogenesis, as well as aiding the development of novel models for studying human diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Active Transport, Cell Nucleus
Animals
Cell Differentiation*
Cell Nucleus / metabolism
Embryonic Development / physiology
Humans
Nuclear Pore / physiology*
Protein Binding
Protein Processing, Post-Translational
Protein Transport