Structure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 Rev protein function

Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13405-9. doi: 10.1002/anie.201306665. Epub 2013 Nov 8.
No abstract available

Keywords: HIV; RNA; drug design; small-molecule inhibitors; terphenyls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology*
  • Binding Sites
  • Dose-Response Relationship, Drug
  • Drug Design*
  • HIV-1 / drug effects
  • Humans
  • Molecular Structure
  • RNA / chemistry*
  • Structure-Activity Relationship
  • Terphenyl Compounds / chemical synthesis
  • Terphenyl Compounds / chemistry
  • Terphenyl Compounds / pharmacology*
  • Virus Replication / drug effects
  • rev Gene Products, Human Immunodeficiency Virus / antagonists & inhibitors*
  • rev Gene Products, Human Immunodeficiency Virus / metabolism

Substances

  • Anti-HIV Agents
  • Terphenyl Compounds
  • rev Gene Products, Human Immunodeficiency Virus
  • RNA