Abstract
Defining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / virology
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Cohort Studies
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Female
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HIV Infections / immunology*
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HIV Infections / virology*
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HIV-1 / genetics
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HIV-1 / immunology*
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HIV-1 / physiology
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Humans
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Viral Load
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env Gene Products, Human Immunodeficiency Virus / genetics
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env Gene Products, Human Immunodeficiency Virus / immunology
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gag Gene Products, Human Immunodeficiency Virus / genetics
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gag Gene Products, Human Immunodeficiency Virus / immunology
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nef Gene Products, Human Immunodeficiency Virus / genetics
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nef Gene Products, Human Immunodeficiency Virus / immunology
Substances
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env Gene Products, Human Immunodeficiency Virus
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gag Gene Products, Human Immunodeficiency Virus
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nef Gene Products, Human Immunodeficiency Virus