Toll-like receptors are the important pattern recognition receptors of innate immune system, which mediate the immunological defence response against pathogen or endogenous damage associated molecules. Recently, more and more researches indicated that Toll-like receptor 2 played vital roles in the pathophysiology of many cardiovascular diseases, including atherosclerosis, coronary diseases, cardiac ischemia-reperfusion injury. In the current report, we review the research progress on the role of Toll-like Receptor 2 in cardiovascular diseases.