Taking the STING out of cytosolic DNA sensing

Elie J Diner; Russell E Vance

doi:10.1016/j.it.2013.10.011

Taking the STING out of cytosolic DNA sensing

Trends Immunol. 2014 Jan;35(1):1-2. doi: 10.1016/j.it.2013.10.011. Epub 2013 Nov 11.

Authors

Elie J Diner¹, Russell E Vance²

Affiliations

¹ Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
² Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. Electronic address: [email protected].

PMID: 24231656
DOI: 10.1016/j.it.2013.10.011

Abstract

Detection of cytosolic DNA activates a downstream signaling molecule called STimulator of INterferon Genes (STING). Inappropriate or excessive activation of STING can lead to autoimmune disease. A new paper in Cell addresses the important question of how STING-dependent signaling is normally constrained.

Publication types

Editorial
Comment

MeSH terms

Humans
Immunity, Innate*
Intracellular Signaling Peptides and Proteins / metabolism*
Membrane Proteins / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Signal Transduction*

Substances

Intracellular Signaling Peptides and Proteins
Membrane Proteins
Protein Serine-Threonine Kinases