One hundred and seven patients with squamous cell carcinoma of the bladder were reviewed. They form 6.8% of patients with bladder cancer seen in this department. There were more females than males, 1.28 to 1. The patients had a mean age of 67.5 years. Patients were found to have tumors that invariably invaded to the muscle. Almost all tumors were solitary and described as ulcerated or solid (non-papillary) in appearance. Forty-nine patients completed a course of radical megavoltage X ray therapy of whom 35 had T3 cancers, with a complete regression rate of 42.3%. The actuarial local control rate for patients with T3 squamous cancer was 33.7% at 3 years. Their survival, however, was poor, being only 18.3% at 3 years.